List of Contraindicated & Safe Medicines in Pregnancy

List of Contraindicated & Safe Medicines in Pregnancy-
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List of Contraindicated & Safe Medicines in Pregnancy

Pregnancy is period from conception to birth. After the egg is fertilized by a sperm and then implanted in the lining of the uterus, it develops into the placenta and embryo, and after a specific time it is converted into a fetus. Duration of pregnancy is about 40 weeks long, which starts from the first day of the woman’s last menstrual period, and is divided into three trimesters, each lasting three months.

List of Contraindicated & Safe Medicines are :

Category  Uncertain/Unsafe Uncertain/Unsafe
Antiemetics (Morning Sickness) Ondansetron, Domperidone(CI) Promethazine, Doxylamine, Dicyclomine,
Prochlorperazine, Metoclopramide
Peptic Ulcer Cimetidine, lansoprazole, Mosapride Ranitidine,Famotidine,Omeprazole,Pantoprazole
Laxative Senna, Bisacodyl, Docusates, Saline purgative Dietary fibre, Ispaghula, Lactose
Analgesic Aspirin, NSAIDs, COX-2 Inhibitor, Codeine, Pethidine, Morphine (CI) Paracetamol, Ibuprofen(The dose Should be minimum)
Antiallergic Dextromethorphan,Bromhexine, Expectorants Nasal drops of- Xylometazoline, Oxymetazoline,
Budesonide.
Antibiotic (Most used) Cotrimoxazole,Fluoroquinolones (CI) Tetracycline (CI) , Doxycycline (CI) Chloramphenicol (CI)Gentamicin, Streptomycin (CI) Kanamycin (CI) Tobramycin (CI) Clarithromycin, Azithromycin, Vancomycin, Clindamycin Penicillin G, Ampicillin, Amoxicillin-Clavulanate,
Cloxacillin, Erythromycin, Piperacillin,
Cephalosporin.
Antitubercular Streptomycin Isoniazid, Rifampicin, Ethambutol,Pyrazinamide
Anti Amoebic Metronidazole, Tinidazole, Quinidochlor Diloxanide Furoate, Paromomycin
Antimalarial Artemether, Artesunate, Primaquine Chloroquine, Mefloquine, Proguanil, Quinine
(For 1st trimester)
Anthelmintic Albendazol(CI) Menendazole (CI) Invermectin, Pyrantel pamoate, Diethylcarbamazine (CI) Piperazine, Niclosamide, Praziquantel
Antifungal Amphotericin B (CI)Fluconazole, Iitraconazole (CI)
Ketoconazole (CI) Grisofulvin (CI) ,Terbinafine
Cotrimazole, Nystatin, Tolnaftate
Antihypertensive ACE Inhibitor (CI) Angiotensin antagonist (CI) Thiazide diuretic, Furosemide, Propranolol, Nitroprusside Methyldopa, Hydralazine, Atenolol, Metoprolol,
Pindolol, Nifedipine, Prazocin, Clonidine
Antidiabetic Sulfonylureas (CI) Metformin (CI) Pioglitazine, Repaglinide, Nateglinide, Acarbose (CI) Human Insulin
Anti Thyroid Carbimazole, Radioactive Iodine (CI) Iodine Propylthiouracil
Antipsychotic Chlorpromazine, Fluphenazine (CI) Clozapine, Olanzapine, Risperidone Haloperidol, Trifluoperazine
Antidepressant Trimipramine (CI) Dothiepin (CI) Sertraline, Paroxetine, Citalopram, Trazodone, Venlafaxine, Moclobemide Amitriptyline, Imipramine, Fluoxetine
Anticoagulant Warfarin (CI) Acenocoumarol, Phenindione (CI) Heparin (unfractionated and LMW)
Antiasthamatic Theophylline, Ketotifen (CI) Montelukast, Zafirlukast, Systemic corticosteroids. Salbutamol, Ipratropium bromide, Beclomethasone
  • CI – Contraindicated

Reference-  KD Tripathi, Essential of medical pharmacology


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