Medicinal Chemistry Questions for Loksewa and License Exam

Medicinal Chemistry Questions for Loksewa and License Exam
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Medicinal Chemistry Questions for Loksewa and License Exam

Some Important Questions for Nepal Pharmacy Council License exam and Pharmacy Loksewa Preparing Students. More than 10 questions always asked from the medicinal chemistry. I hope these questions will help you

1. Which of the following is aryl sulfonamide derivative?

  1. Tamsulosin
  2. Prazosin
  3. Metaraminol
  4. None

2. Paracetamol undergoes metabolism by

  1. N-hydroxylation
  2. Deamination
  3. O-dealkylation
  4. Oxidative deamination

3. Phenobarbital is classified as a

  1. Short-acting barbiturate
  2. Long acting-barbiturate
  3. Intermediate acting barbiturate
  4. Ultra-short-acting barbiturate

4. Toxic metabolite of paracetamol which causes hepatotoxicity is

  1. N-acetyl p-benzoquinone imine
  2. N-acetyl p-benzoquinone amine
  3. O-dealkyl acetaminophen
  4. None

5. The basic ring present in amiodarone is

  1. Benzothiazole
  2. Benzopyrole
  3. Benzofuran
  4. Phenothiazine

6. The basic ring present in atorvastatin is:

  1. Indole
  2. Pyrrole
  3. Napthalene
  4. None of above

7. Which one is strong in action?

  1. Laxative
  2. Purgative
  3. Cathartics
  4. All of above

8. One of the following diuretics is similar to that of diazoxide:

  1. Acetazolamide
  2. Furosemide
  3. Mannitol
  4. Chlorthiazide

9. Which of the following is without heterocyclic ring?

  1. Nelfinavir
  2. Loviride
  3. Troviridine
  4. Zidovudine

10 What is the chemical name of penicillin V?

  1. Phenoxy methyl penicillin
  2. Benzyl penicillin
  3. D- alpha-amino-p-hydroxy ethyl penicillin
  4. 2,6-dimethoxyphenyl penicillin

11. Nitrazepam can be synthesized from

  1. 2-bromo-5-amino benzophenone
  2. 2-Nitro-2-chloro acetophenone
  3. 2-Amino-5-nitro cyclohexanone
  4. 2-Amino-5 nitro-benzophenone

12. Clavulanic acid has a beta lactam ring fused to

  1. Thienyl system
  2. Thiodiazole system
  3. Thiazolidine system
  4. Oxazolidine system

13. Ethambutol molecule has 

  1. Two chiral centers and 3 stereoisomers
  2. Two chiral centers and 4 stereoisomers 
  3. Two chiral centers and 2 stereoisomers
  4. One chiral centers and 2 stereoisomers

14. In thiazides following substituent is essential for diuretic activity

  1. Chloro group at position 6
  2. Methyl group at position 2
  3. Sulphamoyl group at position 7 
  4. Hydrophobic group at position 3

15. Proton pump inhibitors like omeprazole and lansoprazole contain the following ring system:

  1. Pyrimidine
  2. Benzimidazole 
  3. Benzothiazole
  4. Oxindole

16. Identify the name of structure.

Medicinal Chemistry Questions for Loksewa and License Exam

  1. Albendazole
  2. Ciprofloxacin 
  3. Nimesulide
  4. None of above

17. Which is basic ring present in sulfomethoxazole?

  1. Oxazole
  2. Isoxazole
  3. Thiazole
  4. None of the above

18. Which of the following is not a synthetic drug?

  1. Isoniazide
  2. Rifampin
  3. Pyrazinamide 
  4. Ethionamide

19. Sulfonamides are metabolized by humans principally by

  1. Acetylation
  2. Deamination
  3. Oxidation
  4. Conjugation

20. Which of the steroids have neuromuscular blocking activity?

  1. Estrogen
  2. Pancuronium
  3. Fusidin
  4. Digitoxigenin

21. Barbiturates are

  1. Derived from malonic acid
  2. Cyclic ureides
  3. Urea derivatives
  4. All of the above

22. Which isomer of ibuprofen is more active?

  1. S (–) isomer
  2. R (–) isomer
  3. S (+) isomer 
  4. R (+) isomer

23. Which of following bound 99% to protein?

  1. Ibuprofen
  2. Flubiprofen
  3. Naproxen
  4. All

24. 4-diethyl amino 1-methyl butyl amino is side chain of  following agents

  1. Chloroquin
  2. Primaquin
  3. None of the above
  4. Both (a) and (b)

25. Which of following selective β-agonists contains pyridine ring?

  1. Albuterol
  2. Pirbuterol
  3. Terbutaline
  4. None

26. Name of drug is………

Medicinal Chemistry Questions for Loksewa and License Exam

  1. Paracetamool
  2. Aspirin 
  3. Digoxin
  4. None

27. Identify the name of mention structure.

Medicinal Chemistry Questions for Loksewa and License Exam

  1. Mebendazole
  2. Niclosamide
  3. Tinidazole
  4. Albendazole 

28. Select the name of drug

Medicinal Chemistry Questions for Loksewa and License Exam

  1. Toresemide
  2. Cefepime
  3. Frusemide 
  4. Chlorquine

29. Metronidazole can be synthesized from

  1. 2-methylimidazole
  2. 4- nitroimidazole
  3. 3- methyl pyrazole
  4. 5- nitropyrazole

30. Which of the following heterocyclic rings is present in reserpine drug

  1. Indole 
  2. Benzimidazole
  3. Imidazole
  4. Pyrrole

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(1) Comment

  • Ehsan August 1, 2020 @ 4:33 pm

    This is better way

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