Nepal Pharmacy Council License Exam Questions For Pharmacist and Assistant Pharmacist

Nepal Pharmacy Council License Exam Questions For Pharmacist and Assistant Pharmacist
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Nepal Pharmacy Coucil License Exam Questions for Pharmacist and Assistant Pharmacist, questions are collection of previous year exam based on the memory of our students. These question also helpful for Pharmacy officer and Pharmacy Supervisor LokSewa aayog preparing students.We know there are 100 questions for Assistant Pharmacist  and 150 questions for Pharmacist according to Nepal Pharmacy Council syllabus but we are not able to do it due to lack of time.


  1. The constituent of Cochineal is
    a. Cantharidin
    b. Hirudin
    c. Tannic acid
    d. Carminic acid
  2. Tropane alkaloids are biosynthesized from
    a. Phenylalanine
    b. Tyrosine
    c. Ornithine
    d. Leucine
  3. Identify the correct pair of the following
    a. Sympathetic stimulation : Bronchoconstriction
    b. Parasympathetic stimulation : Secretion of gastric juice
    c. Sympathetic stimulation : Contraction of pupil
    d. Parasympathetic stimulation : Dilation of pupil
  4. Which of the following antipsychotic drugs , at low doses, is combined with antidepressants in treatment resistant depression
    a. Chlorpromazine
    b. Haloperidol
    c. Risperidone
    d. Fluphenazine
  5. The management of type-B adverse drug reaction is
    a. To reduce the dose
    b. To withhold the dose and avoid in the future
    c. To increase the dose
    d. To reintroduce and withdraw slowly
  6. Bitot’s spots are seen due to the deficiency of
    a. Vitamin- A
    b. Vitamin- B
    c. Vitamin- C
    d. Vitamin- D
  7. The enzyme HMG-CoA reductase is involved in the pathogenesis of
    a. Renal failure
    b. Alzheimer disease
    c. Atherosclerosis
    d. Parkinson disease
  8. Which of the following is shortest acting cholinesterase inhibitor enlisted below
    a. Neostigmine
    b. Pyridostigmine
    c. Edrophonium
    d. Physostigmine
  9. Which of the following is suitable antidote for mercury poisoning
    a. Atropine
    b. Dimercaprol
    c. Naloxone
    d. Nalorphine
  10. Histamine concentration is highest in
    a. Beta cells
    b. Mast cells
    c. Lymphocytes
    d. Adipocytes
  11. Which is non-resistance to β- lactamase
    a. Methicillin
    b. Oxacillin
    c. Ampicillin
    d. Cloxacillin
  12. The mechanism of action of ciprofloxacin is
    a. Inhibition of protein synthesis by interacting with 30s ribosome
    b. Inhibition of protein synthesis by interacting with 50s ribosome
    c. Inhibition of DNA synthesis by interacting with topoisomerase
    d. Inhibition of cell was synthesis
  13. Which of the following describes the effect of Sodium cromoglycate
    a. Mast cell degranulation
    b. Mast cell stabilization
    c. Leukotriene antagonism
    d. Glucocorticoid receptor agonism
  14. Identify antihistamine drug with additional serotonin receptor blocking activity and good appetite stimulant property
    a. Cyproheptadine
    b. Cimetidine
    c. Ranitidine
    d. Chlorpheniramine
  15. Which is NOT true for Furosemide
    a. Causes hypokalemia
    b. Causes hypouricemia
    c. Causes hypomagnesemia
    d. Acts by inhibiting sodium reabsorption
  16. The colour of phenolphthalein in alkali medium is
    a. Pink
    b. Colourless
    c. Blue
    d. Orange
  17. Drug acting as cardioselective beta blocker is
    a. Labetalol
    b. Atenolol
    c. Propranolol
    d. None of these
  18. Given the following which one is the oleaginous base
    a. White petrolatum
    b. Hydrous lanolin
    c. Anhydrous lanolin
    d. None of these
  19. Baking soda is a common name for
    a. Sodium carbonate
    b. Sodium bicarbonate
    c. Potassium carbonate
    d. Sodium citrate
  20. Hammer mill work on the principle of
    a. Impact
    b. Compression
    c. Combined impact and attrition
    d. Cutting
  21. Wagner’s test is used to detect the presence of
    a. Steroids
    b. Alkaloids
    c. Glycosides
    d. Terpenes
  22. Containers used for aerosols should withstand a pressure of
    a. 130-150 Psig at 130 °F
    b. 140-170 Psig at 130 °F
    c. 140-170 Psig at 120 °F
    d. 120-140 Psig at 120 °F
  23. Alkaloids in cinchona bark are determine by
    a. Nessler’s reagent
    b. Iodine test
    c. Thalloiquine test
    d. Wagner’s test
  24. As per IP, the percentage of sucrose in simple syrup is
    a. 56 % w/w
    b. 66.7 % w/v
    c. 66.7 % w/w
    d. 85 % w/w
  25. The order of dissolution of different dosage forms of drug is
    a. Metastable > stable > amorphous
    b. Stable > amorphous > metastable
    c. Amorphous > metastable > stable
    d. Amorphous > stable > metastable
  26. If the drug is susceptible to hydrolysis then which of the following is suitable
    a. Direct compression
    b. Film coating by organic solvent
    c. Injectable emulsions
    d. None of the above
  27. Most common Phase- II reaction is
    a. Sulfate conjugation
    b. Glucuronide conjugation
    c. Amino acid conjugation
    d. Methylation
  28. Biopharmaceutical classification system is based on
    a. Molecular weight, partition coefficient and dipole moment
    b. Solubility parameter, dissolution and partition coefficient
    c. Solubility, dissolution and permeability
    d. Crystal structure, partition coefficient and dielectric constant
  29. Indicator used in complexometric titration
    a. Murexide
    b. Eriochrome black T
    c. Both a and b
    d. None
  30. According to Lewis Theory, acids are
    a. Proton acceptor
    b. Proton donor
    c. Electron acceptor
    d. Electron donor
  31. The fixation of price by the government is mentioned in which of the following section
    a. Section 26
    b. Section 27
    c. Section 24
    d. Section 30
  32. To fix the price of the drug is the functions of
    a. Drug advisory committee
    b. Drug consultative committee
    c. Pharmacy council
    d. None
  33. Who is the chairman of Drug Advisory Committee
    a. Secretary , ministry of finance
    b. Administrator ,DDA
    c. Secretary , ministry of health
    d. Director general , Department of health Services
  34. Which section and subsection of national drug policy 1995 has enforced the prudent use of antibiotics?
    a. 4.3.3
    b. 5.2.2
    c. 3.3.3
    d. None
  35. When was Nepalese National Formulary (NNF) 1st edition published?
    a. 1991 AD
    b. 1995 AD
    c. 1997 AD
    d. 1998 AD
  36. In pharmacy , a.c. means
    a. Before meal
    b. After meal
    c. Of each
    d. None
  37. 1 drop contain
    a. 0.06 ml
    b. 0.6 ml
    c. 0.006 ml
    d. 0.59 ml
  38. Throat paints are used for
    a. Cough
    b. Pain in throat
    c. Coloring the throat
    d. Mouth and throat infection
  39. Most commonly used diluents in tablet manufacturing is
    a. Starch
    b. Lactose
    c. HPMC
    d. Talc
  40. Enteric coated tablet is disintegrated in
    a. Mouth
    b. Stomach
    c. Intestine
    d. Liver
  41. Viscosity enhancer in ophthalmic preparation is
    a. Povidone
    b. Macrogal
    c. Dextran
    d. Polyvinyl alcohol
  42. The liquid dosage form intended for introduction into rectum is known as
    a. Lozenges
    b. Draught
    c. Enema
    d. Syrup
  43. Rectified spirit means
    a. 99 % w/w ethyl alcohol
    b. 90 % w/w ethyl alcohol
    c. 89 % w/w ethyl alcohol
    d. 50 % w/w ethyl alcohol
  44. Which of the following types of stomata is present in digitalis
    a. Diacytic
    b. Paracytic
    c. Anisocytic
    d. Anomocytic
  45. The solvent used for the extraction process is known as
    a. Menstruum
    b. Marc
    c. Fluid
    d. Extract
  46. Which of the following has more alcohol soluble extractive value
    a. Aloe
    b. Siam benzoin
    c. Ginger
    d. Myrrh
  47. Olive oil is extracted from
    a. Ricinus communis
    b. Olea europoea
    c. Prunus amygdalus
    d. Gossypium hirsutam
  48. The characteristic properties of an acid is due to the presence of
    a. Hydride ions
    b. Hydroxyl ions
    c. Hydronium ions
    d. Oxide ions
  49. The fluid exiting in a chromatographic column is known as
    a. Eluent
    b. Eluate
    c. Analyte
    d. All of above
  50. In normal phase chromatography, stationary phase is
    a. Non polar
    b. Polar
    c. Neutral
    d. None of the above
  51. Fusidic acid is
    a. Antifungal
    b. Antiviral
    c. Antibiotic
    d. None of the above
  52. Which of the following is most likely to cause tinnitus in high doses
    a. Ibuprofen
    b. Aspirin
    c. Indomethacin
    d. Mefenamic acid
  53. Gingival hyperplasia is a common side effect associated with prolonged treatment with
    a. Phenytoin
    b. Diazepam
    c. Phenobarbitone
    d. Trimethadione
  54. Drug causing folate deficiency is
    a. Isoniazid
    b. Methotrexate
    c. Erythromycin
    d. Cloxacillin
  55. Morphine is not recommended to be used in head injury because
    a. It causes release of histamine
    b. It is addictive
    c. It raises intracranial pressure
    d. All of the above
  56. Choose the ulcer protective agent
    a. Sucralfate
    b. Cimetidine
    c. Pirenzepine
    d. Lansoprazole
  57. A 30 year old asthmatic patient has been diagnosed as having essential hypertension. In treating him which of the following drug is most appropriate
    a. Atenolol
    b. Labetalol
    c. Clonidine
    d. Pindolol
  58. Most serious side effect of penicillin therapy is
    a. Renal damage
    b. Fatty liver
    c. Anaphylactic shock
    d. 8th cranial nerve damage
  59. Anti-asthmatic agent ineffective orally
    a. Sodium chromoglycate
    b. Salbutamol
    c. Theophylline
    d.Doxfylline
  60. Secobarbitone is
    a. Long acting barbiturate
    b. Short acting barbiturate
    c. Ultra-short acting barbiturate
    d. Intermediate acting barbiturateAnswers
  61. Particle size of the drug affect
    a. Absorption
    b. Dissolution
    c. Bioavailability
    d. All
  62. Sterilization by moist heat is carried out a
    a. 115°C for 60 min
    b. 115°C for 30 min
    c. 150°C for 30 min
    d. 160°C for 60 min
  63. …………. Is used as preservative in parenteral preparatio
    a. Phenol
    b. Benzoic acid
    c. Benzalkonium chloride
    d. Chlorocresol
  64. Slightly soluble means solubility of 1 gm of substance in ………….of the solvent
    a. 30-100 ml
    b. 100-1000 ml
    c. 1000-10000 ml
    d. None of the above
  65. Shellac is used as
    a. Diluents
    b. Polishing agent
    c. Enteric coating agent
    d. Binder
  66. Synthetic catecholamine
    a. Isoproterenol
    b. N-methyl noradrenaline
    c. Noradrenaline
    d. Dopamine
  67. Ability of the drug to combine with receptors is best described as
    a. Affinity
    b. Intrinsic activity
    c. Agonistic activity
    d. Efficacy
  68. Which vitamin has structure similar to steroid
    a. A
    b. D
    c. C
    d. K
  69. Millions reagent is used to detect
    a. Proteins
    b. Gums
    c. Tannin
    d. Oleo gum resins
  70. The pink color of calamine is due to the presence of
    a. Cobalt chloride
    b. Methyl orange
    c. Zinc oxide
    d. Ferric oxide
  71. Heroine is
    a. Dimethyl morphine
    b. Diacetyl morphine
    c. Dimethoxy morphine
    d. None of the above
  72. Sulphur containing amino acid is
    a. Tyrosine
    b. Alanine
    c. Cysteine
    d. Phenylalanine
  73. Dihydrofolate reductase is inhibited by
    a. Trimethoprim
    b. Sulfamethoxazole
    c. Antabuse
    d. Metronidazole
  74. Following are the barriers of effective communication except …….
    a.Environment
    b.Law regarding pharmacy practice
    c.Time
    d.pharmacist
  75. Parkinsonism is characterized by
    a. Akinesia
    b. Tremors
    c. Rigidity
    d. All of the above
  76. Allopurinol inhibits
    a. Adenylate cyclase
    b. Carbonic anhydrase
    c. Xanthine oxidase
    d. None of the above
  77. Passive immunity is obtained by injecting
    a. Antiserum
    b. Antigens
    c. Vaccines
    d. Antibodies
  78. The extraction process where powdered crude drug is kept in contact with suitable solvent for suitable time
    a. Percolation
    b. Decoction
    c. Maceration
    d. Reversed percolation
  79. Effective management of drug will
    a. Ensure constant supply
    b. Minimize wastage of resourcesc.
    c. Reduce price of drug
    d. All of above
  80. One among the following is an alkylating anticancer drug
    a. Chloramphenicol
    b. Chlorambucil
    c. Chlorhexidine
    d. Clotrimazole
  81. Provision of clinical trail is related to which section of drug act 2035;
    a. Section 11
    b. Section 41
    c. Section 21
    d. Section 31 
  82. The surface material from a tablet that is sticking to and being removed from the tablet surface by a punch is known as
    a. Capping
    b. Lamination
    c. Sticking
    d. Picking
  83. Castor oil is
    a. Nondrying oil
    b. Semi drying oil
    c Drying oil
    d. Super drying oil
  84. Meuroxide test is used for identification of
    a. Purine
    b. Tropane
    c. Quinolone
    d. Indole
  85. A 48 year old man presents to the emergency room with severe headache and blurred vision. His blood pressure is 230/140. Ophthalmologic examination reveals blurred optic discs with indistinct margins. An intravenous drip of sodium nitroprusside is started. What is the mechanism of action of this medication?
    a. Alpha adrenergic antagonist
    b. Ganglion blocker
    c. Direct smooth muscle vasodilator
    d. ACE inhibitor
  86. Lupus like syndrome is shown by
    a. Hydralazine
    b. Levothyroxine
    c. Amitriptyline
    d. Ibuprofen
  87. In Kjeldahl method, sample containing nitrogen is digested with
    a. Conc. NaOH
    b. Fuming HNO3
    c. Conc. H2SO4
    d. Strong NH3 solution
  88. In Gas-Liquid Chromatography, some of the samples need to be derivatized in order to increase their
    a. Solubility
    b. Thermal conductivity
    c. Polarizability
    d. Volatility
  89. Nicotinic action of acetylcholine is blocked by the drug
    a. Atropine
    b. Carvedilol
    c. Neostigmine
    d. D-tubocurarine
  90. Improvement of memory in Alzheimer’s disease is bought about by drugs which increases transmission in
    a. Cholinergic receptors
    b. Dopaminergic receptors
    c. GABA receptors
    d. Adrenergic receptors
  91. Essential oil is the other name for
    a.Volatile oil.
    b.Fixed oil
    c.Mineral oil.
    d.None
  92. Which of the following plant is used as laxative?
    a. Rhubarb
    b. Rubus
    c. Rauwolfia
    d. Rhododendron
  93. TMS is used for the reference compound for …..
    a. NMR spectroscopy
    b. IR spectroscopy
    c. Mass Spectroscopy
    d. UV spectroscopy
  94. Liquid paraffin exhibits
    a. Plastic flow
    b. Newtonian flow
    c. Dilatant flow
    d. Pseudoplastic flow
  95. Colour of methyl orange indicator in alkali will be ….
    a. Red
    b. Pink
    c. Orange
    d. Yellow
  96. One of the following drug synthesis is based on fischer indole synthesis
    a. Indomethacin
    b. Ibuprofen
    c. Lignocaine
    d. Benzocaine
  97. नेपाल स्तर नियामवलि २०४३ अनुसार हर्मोन समुहको औसधि कुन समुहमा पर्छ््न ?
    a.समुह क
    b.समुह ख
    c.समुह ग
    d.समुह घ
  98. नेपाल सरकार लाई औसधि सम्बन्धि शैदान्तिक तथा प्रशासनिक बिषयमा परामर्श कुन संस्था ले दिने गर्दछ ?
    a. औसधि सल्लहाकार समिति
    b. नेपाल फार्मेसी परिसद
    c. औसधि ब्यवस्था बिभाग
    d. औसधि परामर्स समिति
  99. How many parts of 10% ointment to be mixed with 2 parts of 15% ointment to get 12% ointment?
    a.2
    b.3
    c.5
    d.6
  100. Pharmacopoeias could be a vital reference tool for people and organization involved in pharmaceutical
    a.Research
    b.Development
    c. Quality control and analysis
    d.All

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