Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old. Due to concerns about the risk of hepatotoxicity, nimesulide has been withdrawn from market in many countries.
- Acute Pain
- Osteoarthritic Pain
Mechanism of Action
The therapeutic effects of Nimesulide are the result of its complete mode of action which targets a number of key mediators of the inflammatory process such as: COX-2 mediated prostaglandins, free radicals, proteolytic enzymes and histamine.
Due to concerns about the risk of liver toxicity, nimesulide has been withdrawn from market in several countries (Spain, Finland, Belgium, Ireland, and United States). Liver problems have resulted in both deaths and the need for transplantation. This may occur in as little as three days after starting the medication.
Continuous use of nimesulide (more than 15 days) may cause the following side effects:
- Skin rash
- Bitterness in mouth
- Heart burn
- Epigastric pain
Special Precautions while taking Nimesulide.
- Renal impairment
- Heart failure
- Alcohol abuse
- Crohns disease
- Gastric ulcer
- Diabetis mellitus
- Hepatic failure
- Rectal irritation or bleeding
The usual Adult dose of Nimesulide 100mg BD.
If Dose Missed
Interaction with Medicine
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