Some Important Drug Interaction Pharmacy Students Must Know

Important Drug Interaction For Pharmacy Students
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Some Important Drug Interaction Pharmacy Students Must Know

Drug  Drug Interaction 
Acetaminophen CYP inducers – such as phenytoin and carbamazepine increases rate of NAPQI production which leads to liver toxicity after acetaminophen overdose
Epinephrine Beta Blockers can induce widespread vasoconstriction
Antacids Divalent ions reduce serum concentration of drug like thyroxine, tetracyclines, digoxin and PPIs
Albendazole Plasma concentration lowered by phenytoin and carbamazepine.

Cimetidine increases albendazole concentration.

Aminoglycosides Loop diuretics / Vancomycin increases ototoxicity risk.
Aspirin Antiplatelets and anticoagulant drugs increase risk of bleeding.
Calcium Oral calcium reduces absorption of bisphosphonates, tetracyclines and levothyroxine.
Clopidogrel CYP 450 inhibitors block its activation – omeprazole, erythromycin, antifungals, SSRIs etc.
Corticosteroids NSAIDs increase risk of peptic ulceration/bleeding.
Digoxin Digoxin toxicity increases when taken with loop or thiazide diuretics, amiodarone, calcium channel blockers, spironolactone and quinine.
Fluoroquinolones NSAIDs increase risk of seizures, prednisolone increase tendon rupture risk.
Insulin Taking insulin with systemic corticosteroids increases insulin requirments.
Iron Reduces absorption of levothyroxine, bisphosphonates and tetracyclines.
Isoniazid Increases acetamenophen toxicity.
Metformin Prednisolone and diuretics reduce efficacy of metformin
Metronidazole Increases risk toxicity of phenytoin, lithium.
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