Some Important Drug Interaction Pharmacy Students Must Know
|Acetaminophen||CYP inducers – such as phenytoin and carbamazepine increases rate of NAPQI production which leads to liver toxicity after acetaminophen overdose|
|Epinephrine||Beta Blockers can induce widespread vasoconstriction|
|Antacids||Divalent ions reduce serum concentration of drug like thyroxine, tetracyclines, digoxin and PPIs|
|Albendazole||Plasma concentration lowered by phenytoin and carbamazepine.
Cimetidine increases albendazole concentration.
|Aminoglycosides||Loop diuretics / Vancomycin increases ototoxicity risk.|
|Aspirin||Antiplatelets and anticoagulant drugs increase risk of bleeding.|
|Calcium||Oral calcium reduces absorption of bisphosphonates, tetracyclines and levothyroxine.|
|Clopidogrel||CYP 450 inhibitors block its activation – omeprazole, erythromycin, antifungals, SSRIs etc.|
|Corticosteroids||NSAIDs increase risk of peptic ulceration/bleeding.|
|Digoxin||Digoxin toxicity increases when taken with loop or thiazide diuretics, amiodarone, calcium channel blockers, spironolactone and quinine.|
|Fluoroquinolones||NSAIDs increase risk of seizures, prednisolone increase tendon rupture risk.|
|Insulin||Taking insulin with systemic corticosteroids increases insulin requirments.|
|Iron||Reduces absorption of levothyroxine, bisphosphonates and tetracyclines.|
|Isoniazid||Increases acetamenophen toxicity.|
|Metformin||Prednisolone and diuretics reduce efficacy of metformin|
|Metronidazole||Increases risk toxicity of phenytoin, lithium.|
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