Pharmacology MCQs Antipsychotic Drugs

Pharmacology MCQs Antipsychotic Drugs for Pharmacy students which is helpful for various types of pharmacy compitative exams.

1. A drug that depresses the CNS produces calm and suppress bodily reaction but does not induce sleep
a. Antipsychotic
b. Pain killer
c. Anxiolytics
d. Hypnotics
e. Sedatives

2. Administration of an MAO inhibitor would most likely cause changes in the CNS concentration of:
a. Acetylcholine
b. Histamine
c. Norepinephrine
d. All of the above

3. Buspirone:
a. Effective in treating depression
b. Cross-tolerant with benzodiazepines
c. Does not produce significant levels of sedation
d. Benzodiazepine
e. Has a rapid onset of action

4. Which of the following is not an anti-depressant drugs?
a. Tricyclic antidepressants
b. MAOI
c. SSRIs
d. Antinoaminetritaserehibitor (ATRs).

5. The most effective drug in status epilepticus in adults is :
a. Carbamazepine
b. Ethosuximide
c. Diazepam
d. Zonisamide

6. The drug which is used for myoclonic seizures is
a. Primidone
b. Carbamazepine
c. Clonazepam
d. Phenytoin

7. Sodium Valproate is very effective against all the following except:
a. Absense Seizures
b. Myoclonic seizures
c. Generalized tonic-clonic seizures
d. Partial seizures

8. Phenobarbital causes:
a. Physical and Phychological dependence
b. Exacerbation petit mal epilepsy
c. Sedation
d. All of the above

9. Regarding Phenytoin:
a. It effect on Calcium current reducing the low threshold[T-type] current
b. It blocks Na [Sodium] channels
c. It inhibit GABA-transaminase, which catalyzes the breakdown of GABA

10. The mechanism of action of Carbamazepine appears to be similar to that of:
a. Benzodiazepines
b. Sodium Valproate
c. Phenytoin
d. Ethosuximide

11. Which of the following anti-epileptic drug may produce teratogenicity?
a. Phenytoin
b. Valproate
c. Topiramate
d.. All of the above

12. Which of the following does not induce hepatic microsomal enzyme ?
a. Carbamazepine
b. Phenytoin
c. Phenobarbital
d. Sodium valproate

13. What are the most common adverse effects of anticonvulsive drugs?
a. Headache and dizziness
b. Gastrointestinal symptoms
c. Alternation of cognition and mentation
d. Adverse effects on appetite and body weight
e. All of the above

14. Which of the following is not MAO-A inhibitor
a. Selegiline
b. Brofaromine
c. Clorgyline
d. Moclobemide

15. MAO inhibitors in general raise the brain level of
a. Dopamine
b. Serotonin
c. Nor adrenaline
d. All of the above

16. Atypical antidepressant is
a. Selegiline
b. Trazodone
c. Desipramine
d. Doxeptan

17. Benzodizepine action is associated with this neurotransmitter system:
a. Cholinergic
b. Adrenergic
c. Glycine
d. Glutamate
e. GABA

18. Lithium toxicity may manifest as
a. Polyuria
b. Nephrotic syndrome
c. Renal calculi
d. Acute renal failure
19. The mechanism of action of barbiturates differs from that of benzodiazepines in that they
a. Do not affect the GABA–benzodiazepine receptor–chloride channel complex
b. Act as inverse agonists at the benzodiazepine receptor
c. Increase the frequency of chloride channel opening without affecting its life time
d. Have both GABA–facilitatory as well as GABA–mimetic actions

20. Which of the following tricyclic antidepressant drugs is a preferred drug in the treatment of obsessive – compulsive dirorder ?
a. Amitriptyline
b. Amoxapine
c. Clomipramine
d. Doxepin
e. All the above
f. None of the above

21. A 65-year-old man was brought to the hospital with complaints of pain in lower abdomen and not having passed urine for 16 hours. The bladder was found to be full. His son informed that he was depressed for the last 2 years and only the day before a doctor had given him some medicine. Which of the following drugs is he most likely to have received ?
a. Alprazolam
b. Haloperidol
c. Imipramine
d. Trazodone

22. The antidepressant which selectively blocks 5- hydroxytryptamine uptake is
a. Desipramine
b. Amoxapine
c. Fluoxetine
d. Dothiepin

23.Concurrent use of carbamazepine and phenyton will lead to
a. Increased metabolism of phenyton
b. Decreased metabolism of phenytoin
c. No change in the metabolism of phenytoin
d. All of above

24. Duration of barbiturate action mainly depends on:
a. Rate of hepatic metabolism
b. Excretion rate from renal and/or pulmonary systems
c. Lipid solubility and time to distribute throughout the body
d. Pharmacogeneticdifferents between patients

25. Shortest-acting benzodiazepine:
a. Diazepam
b. Orazepam
c. Triazolam
d. Clonazepam
e. Chlordiazepoxide

26. Which of the following is a noncatecholamine sympathomimetic:
a. Adrenaline
b. Ephedrine
c. Dopamine
d. Isoprenaline

27. The following is a selective α2 adrenoceptor antagonist:
a. Prazosin
b. Phentolamine
c. Yohimbine
d. Clonidine

28. The following drug is used to reverse the CNS depression produced by diazepam:
a. Dexamphetamine
b. Doxapram
c. Physostigmine
d. Flumazenil

29. Which of the following is the most suitable drug for a 6- year-old girl suffering from absence seizures with occasional generalized tonic-clonic seizures:
a. Ethosuccimide
b. Sodium valproate.
c. Carbamazepine
d. Phenytoin

30. The antiparkinsonian drug which acts by inhibiting the degradation of dopamine in the brain is:
a. Carbidopa
b. Amantadine
c. Selegiline
d. Bromocriptine