Pharmacology Questions for License and Loksewa Exam

Here we have made some Pharmacology Important MCQs for Pharmacy license exam and pharmacy loksewa exam preparing student. Pharmacology is the major subject of pharmacy, many questions are asked from pharmacology in various types of pharmacy exam

1. `Essential drugs’ are:
   A. Life saving drugs
   B. Drugs that meet the priority health care needs of the population
   C. Drugs that must be present in the emergency bag of a doctor
   D. Drugs that are listed in the pharmacopoia of a country
2. An ‘orphan drug’ is:
   A. A very cheap drug
   B. A drug which has no therapeutic use
   C. A drug needed for treatment or prevention of a rare disease
   D. A drug which acts on Orphanin receptors
3. Drug administered through the following route is most likely to be subjected to first-pass metabolism:
   A. Oral
   B. Sublingual
   C. Subcutaneous
   D. Rectal
4. Majority of drugs cross biological membranes primarily by:
   A. Passive diffusion
   B. Facilitated diffusion
   C. Active transport
   D. Pinocytosis
5. Which of the following drugs is most likely to be absorbed from the stomach:
   A. Morphine sulfate
   B. Diclofenac sodium
   C. Hyoscine hydrobromide
   D. Quinine dihydrochloride
6. Bioavailability of drug refers to:
   A. Percentage of administered dose that reaches systemic circulation in the unchanged form
   B. Ratio of oral to parenteral dose
   C. Ratio of orally administered drug to that excreted in the faeces
   D. Ratio of drug excreted unchanged in urine to that excreted as metabolites
7. The following drug metabolizing reaction is entirely nonmicrosomal:
   A. Glucuronide conjugation
   B. Acetylation
   C. Oxidation
   D. Reduction
8. Drugs which undergo high degree of first-pass metabolism in liver:
   A.Have low oral bioavailability
   B. Are excreted primarily in bile
   C. Are contraindicated in liver disease
   D. Exhibit zero order kinetics of elimination
9. The plasma half life of penicillin-G is longer in the new born because their:
   A. Plasma protein level is low
   B. Drug metabolizing enzymes are immature
   C. Glomerular filtration rate is low
   D. Tubular transport mechanisms are not well developed
10. Select the antibiotic that has a high therapeutic index:
    A. Streptomycin
    B. Doxycycline
    C. Cephalexin
    D. Vancomycin
11. Select the antibiotic whose dose must be reduced in patients with renal insufficiency:
    A. Ampicillin
    B. Chloramphenicol
    C. Tobramycin
    D. Erythromycin
12. A higher incidence of adverse effects to cotrimoxazole occurs when this drug is used for:
    A. Typhoid fever
    B. Whooping cough
    C. Pneumocystis carinii pneumonia in AIDS patients
    D. Chancroid
13. The following quinolone antimicrobial agent is not useful in systemic infections:
    A. Lomefloxacin
    B. Ofloxacin
    C. Nalidixic acid
    D. Pefloxacin
14. For healing duodenal ulcer the usual duration of H blocker therapy is:
    A. 4 weeks
    B. 6 weeks
    C. 8 weeks
    D. 12 weeks
15. Gynaecomastia can occur as a side effect of:
    A. Bromocriptine
    B. Cimetidine
    C. Famotidine
    D. Levodopa
16. The following anticancer drug has high emetogenic potential:
    A. Vincristine
    B. Chlorambucil
    C. 6-Mercaptopurine
    D. Cisplatin
17. Codeine is used clinically as:
    A. Analgesic
    B. Antitussive
    C. Antidiarrhoeal
    D. All of the above
18. Which of the following secretions is not stimulated by acetylcholine:
    A. Tear
    B. Bile
    C. Pancreatic juice
    D. Sweat
19. Actions of pilocarpine include the following except:
    A. Sweating
    B. Salivation
    C. Miosis
    D. Cycloplegia
20. Select the longer acting ocular beta blocker:
    A. Timolol
    B. Betaxolol
    C. Cartiolol
    D. Levobunolol