Drug Induced Pigmentation Skin and Urine

Drug Induced Pigmentation Skin and Urine

Drug-induced pigmentation, or coloring, is a common side effect various drugs. It impacts many of the most commonly used medicines from tetracyclines and antimalarials, to NSAIDs and iron. Drug induces pigmentation topic is one of the frequently asked question in various types of exams i.e. Nepal Pharmacy Council License Exam and Pharmacy Loksewa.

Below, we’ve put together a comprehensive list of 20 drug-induced pigmentation effects that you need to know. You must know all these adverse effects, here we include syndrome like side effect of some drugs.

Drugs	Side Effect
Cimetidine	Blue Urine
Phenytoin	Dark brown skin patches Purple glove syndrome
Nitrofurantoin	Brown Urine
Ethambutol	Red green colour urine
Rifampicin	Red/ Orange Colour Urine, Sweat & Tear
Vancomycin	Red man syndrome
Clofazimine	Brown pink colour pigmentation
Phenazopyridine	Orange urine
Amiodarone	Blue-gray skin discoloration
Tetracyclines	Discoloration / hypoplasia of tooth enamel
Minocycline	Blue-gray skin pigmentation
Iron	Black stools
Bismuth	Black tongue discoloration
Latanoprost	Permanent iris discoloration
Heavy metal salts	Silver discoloration, gold discoloration etc.
Chlorpromazine	Bluish-gray skin pigmentation
Chloroquine	Blue-gray skin pigmentation
NSAIDs	Fixed drug eruptions Erythematous lesions that leave local brown pigmentation. May occur on face,extremities or genitalia.
Cytotoxic drugs	Hyperpigmentation of skin Diffuse pigmentation of nails