Important Drug Antidotes You Need to Know
Important Drug Antidotes You Need to Know
According to WHO, an antidote is defined as a therapeutic substance used to counteract the toxic actions of a specified xenobiotic. Antidotes reduce the overall burden of health service in managing of poisoning cases.
The term antidote is a Greek word “Antididonai” meaning “given against”. In Cambridge dictionary, antidote is defined as a chemical especially a drug that limits the effects of a poison or a way of preventing or acting against something bad Poison + antidote = destroy poisoning.
The antidotes for some particular toxins are manufactured by injecting the toxin into an animal in small doses and extracting the resulting antibodies from the host animals’ blood. This results in an antivenom that can be used to counteract venom produced by certain species of snakes, spiders, and other venomous animals. Some animal venoms, especially those produced by arthropods (such as certain spiders, scorpions, and bees) are only potentially lethal when they provoke allergic reactions and induce anaphylactic shock; as such, there is no “antidote” for these venoms; however anaphylactic shock can be treated (e.g. with epinephrine).
List of Important Drugs Antidotes
Antidote | Drug |
Activated charcoal | Many oral toxins |
Theophylline | Adenosine poisoning |
Beta blockers | Theophylline |
Calcium chloride | Calcium channel blockers Black widow spider bites |
Calcium gluconate | Hydrofluoric acid |
EDTA | Heavy metal poisoning |
Hydroxocobalamin Amyl nitrite Sodium nitrite Succimer | Cyanide poisoning |
Cyproheptadine | Serotonin syndrome / toxicity |
Deferoxamine | Iron poisoning |
Digoxin Immune Fab | Digoxin poisoning |
Flumazenil | Benzodiazepine overdose |
Glucagon | Beta blockers |
100% oxygen | Carbon monoxide |
Idarucizumab | Dabigatran etexilate |
Leucovorin / folinic acid | Methotrexate |
Naloxone | Opioid overdose |
N-acetylcysteine | Acetaminophen |
Octreotide | Oral hypoglycemic drugs |
Pralidoxime chloride | Organophosphates |
Protamine sulfate | Heparin |
Prussian blue | Thallium poisoning |
Physostigmine | Anticholinergics |
Pyridoxine | Isoniazid |
Phytomenadione (vit. K) | Warfarin poisoning |
Sodium bicarbonate | Aspirin, TCAs |
Succimer | Lead poisoning |
Please do not use these medicines without the advice of a health worker as they may have side effects.
- National List of Essential Medicines Nepal
- Emergency Drugs List of Nepal
- List of Narcotic and Psychotropic Drugs
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