Nepal Pharmacy Council License Exam Pharmaceutics MCQs

Nepal Pharmacy Council License Exam Pharmaceutics MCQs for Diploma Pharmacy and Bacehlor of Pharmacy.

1. The intensity of drug action is indicated by

a. AUC
b. Cmax
c. MEC
d. Tmax

Explaniation: More the plasma concentration more will the be drug intensity. AUC determines bioavailability. Tmax determines at what time the concentration of drug is maximum. MEC is the minimum concentration of a drug required to show its action

2. Dilatant material are also referred to as
a. Shear thickening system
b. Shear thinning system
c. Bingham body
d. Both a&b

Explaniation: On applying more stress, the viscosity increases of dilatant material. Pesudoplastic flow is referred to as shear thinning and Bingham body shows plastic flow

3. Match the drug with its sources
a. Kaolin i. Diatomaceous earth
b. Keiselguhr ii. Hydrated aluminum silicate
c. Calamine iii. Hydrated magnesium silicate
d. Talc iv. An ore of zinc oxide with trace of ferric oxide

Explaniation: Kaolin also knows as clay is hydrated aluminum silicate. Keiselguhr is a diatomaceous earth. Calamine, an ore of zinc oxide with ferric oxide. Talc is a hydrate magnesium silicate.

4. Calamine lotion contains
a. Bentonite
b. Zinc oxide
c. Calamine
d. All of the above

Explaniation: Calamine lotion, an OTC medication used to treat mild itchiness, contains active ingredients zinc oxide and 0.5% iron oxide. The iron oxide gives calamine lotion its distinctive pink colour. Inactive calamine lotion ingredients includes, Purified water,Glycerin, Calcium hydroxide and Bentonite magma.

5. The disintegration time for sugar coated tablet is
a. 45 mins
b. 15 mins
c. 60mins
d. 20 mins

Explaniation: Uncoated tablets :15 mins, Coated tablets: 30 mins, Sugar coated tablets: 60 mins Dispersible tablets 3 mins, Orodispersiable: 1 min, Enteric coated tablets: Intact for 1 hour in 0.1N HCl and disintegrate within 2 hour in phosphate buffer, Effervescent tablets : 5 mins

6. Carr’s index is used to determine
a. Particle size
b. Powder flow
c. Elasticity
d. Polymorphis

Explaniation: Carr’s_Index = (ρtapped-ρbulk)/ρtapped*100

Excellent flow : <10 , Good flow : 11-15, Fair : 16-20, Passable : 21-25

7. IVIVC utilizes the principles of statistical moment analysis
a. Level A
b. Level B
c. Level C
d. Level D

8. In sugar coating of tablets seal coating is done to
a. Prevent moisture penetration
b. Round the edge and built tablet size
c. Smoothen surface
d. Prevent tablet breakage due to vibration

Explaniation: Sugar coating is a multistep process containing 4 steps. Sealing for moisture barrier, Sub coating to coat sugar layer, Smoothing or syruping and Polishing. Major disadvantage of sugar coating is that it increases the tablet size by 50-100% of its weight

9. Humectants added in cosmetic preparations generally act by
a. Hydrogen bond formation
b. Covalent bond formation
c. Complex formation
d. The action of London forces

Explaniation: Humectant helps draw moisture to the skin’s surface and retains water so that the skin does not end up drying out quickly. Glycerin , Sorbitol and propylene glycol is commonly used.

10. Transdermal patches can be studied for drug dissolution using one of the types of dissolution apparatus
a. Flow through cell
b. Hansen paddle
c. Paddle over disc
d. Reciprocating holder

Explaniation: Type V (paddle over disc) and Type VI (cylinder) can be used.

11. Sedimentation of particle in a suspension can be minimized by
a. Increasing particle size
b. Decreasing particle size
c. Increasing viscosity of medium
d. Both b & c

12. Most appropriate dryers to be used for following
a. Drum dryer i.Antibiotic solution
b. Fluidized bed dryer ii. Tablet granules
c. Spray dryer iii. Gelatin
d. Freeze dryer iv. Suspension of kaolin

Explaniation: Drum Dryer-Gelatin, FBD-mainly tablet granulation, Spray dryer-suspension, Freeze Dryer-Antibiotic solution

13. Difference between mouthwash and gargle
a. Both oral preparations
b. Gargle is for deodorizing activity
c. Gargle is used to treat throat infection
d. All of the above

Explaniation: Mouthwash is for oral use.

14. A diluent used in tablet formulation is
a. Lactose
b. Starch
c. Dicalcium phosphate
d. All of the above

15. Particle size analysis is mainly done for
a. Dissolution rate
b. Good flow
c. Dose uniformity
d. All of the above

16. Which method would you choose when you work as a production pharmacist for complete blending of potent powders with large quantities of diluents
a.Spatulation
b. Levigation
c. Trituration
d. Geometric dilution

17. BET stands for
a. Bacterial Endotoxin Test
b. Bioequivalence Endotoxin Test
c. Bleach Endotoxin Text
d. Bismuth endotoxin Test

18. Some crystalline substance liberates water of crystallization wholly or partly on exposure to humid atmosphere or during trituration and thus becomes wet and liquefy, are known as
a. Efflorescent
b. Delinquent
c. Hygroscopic
d. None

Explaniation: Deliquescent substances absorb moisture from environment until dissolved in absorbed water and form solution. Efflorescent loses water from its hydrated salts, Hygroscopic absorbs or adsorbs water from its surroundings.

19. Equation pH=pKa + log (ionized/unionized) is for
a. Strong acids
b. Strong bases
c. Weak acids
d. Weak base

20. According to stokes equation the sedimentation rate is inversely proportional to
a. Viscosity of medium
b. Diameter of particle
c. Density of particle
d. All of the above

21. Choose the most appropriate coating materials of respective coating
a. Seal coating i. HPMC
b. Sub coating ii. Carnauba wax
c. Polishing iii. Gelatin
d. Film coating iv. PEG 400

Explaniation: Seal coating – PEG 400, Sub coating – Gelatin, Polishing – Carnauba wax, Film coating-HPMC

22. Preservatives used in eye preparations
a. Phenyl mercuric nitrate
b. Benzalkonium chloride
c. Chlorhexidine acetate
d. All of the above

23. Choose on of the gases commonly used in sterilization of medical products
a. Ethylene oxide
b. Carbon dioxide
c. Nitrous oxide
d. Nitrogen

24. The pH of buffer system can be calculated by
a. Noyes-Whitney equation
b. Henderson Hasselbach equation
c. Michaelis-Menten equation
d. Stokes equation

25. Substances used to reduce friction during tablet compression and facilitate ejection of tablets from die cavity is called as
a. Lubricant
b. Glidant
c. Anti-adherent
d. Humectant

Explaniation: Glidant ( silicates) improves flow property while Anti adherent avoids sticking of granules or tablet material in punches or die wall.

26. Which animal show a physiological response to pyrogens similar to that of human being
a. Rat
b. Guinea pig
c. Rabbit
d. Horse

27. IUPAC stands for
a. International Union of Pure and Applied Chemistry
b. International Unit of Pure and Applied Chemistry
c. International Union of Pure and Advance Chemistry
d. International Unit of Pure and Applied Chemistry

28. In tablet hydroxyl propyl methyl cellulose is used as
a. Diluent
b. Film former
c. Disentigrant
d. Binder

29. Surfactant is characterized by presence of
a. Hydrophobic group in molecule
b. Hydrophilic group in molecule
c. None
d. Both

30. A superdisentigrant in tablet formulation
a. Sodium starch glycollate
b. Starch
c. PVP
d. Mg-aluminum silicate

Explaniation: Sodium starch glycollate (1-8%), Crosscarmellose sodium (2-5%) and Cross povidone (2-5%) are the most commonly used superdisentigrant

31. The concentration of phenyl mercuric nitrate as preservative in eye drop is
a. 0.02 %
b. 0.002 %
c. 0.2 %
d. 2

32. Slugging process is used in following preparation
a. Capsules
b. Tablets
c. Powders
d. Ointments

33. Which of the following is used in enteric coating?
a. CMC
b. CAP
c. HPMC
d. All of the above

Explaniation: HPMC is used for film coating, CAP (Cellulose Acetate Phthalate) and HPMC phthalate is commonly used for enteric coating.

34. The angle of repose is calculated by
a. Tan α = Radius/Height
b. Tan α = 1 + (Radius/Height)
c. Tan α = 1 – (Radius/Height
d. Tan α = Height / Radius

35. Fine particles pass through sieve no.
a. 120
b. 10
c. 85
d. 22

36. Glass used for dry powders and oils solution
a. Type I
b. Type II
c. Type III
d. Type IV

Explaniation: Type I (Neutral or borosilicate)-aqueous injectable &Lab instruments, Type II – acidic and neutral preparations (Treated soda lime glass), Type III (Soda lime)- Oily injectable & Powders, oils, semi solid dosage form, Type NP (General purpose soda lime)- Dry powders, solid and semi solid dosage

37. Soda Ash is also known as
a. Lime stone e
b. Sodium carbonate
c. Pure silica
d. Calcium carbonate

38. Surface tension of water is
a. 62 dynes /cm
b. 72 dynes/cm
c. 82 dynes /cm
d. 92 dynes /cm

39. In cosmetic preparation anti-oxidant used is in aqueous system
a. Sodium formaldehyde sulphoxylate
b. Α-tocopherol
c. Methyl paraben
d. Phenol

40. Example of biphasic liquid dosage form
a. Syrup
b. Emulsion
c. Colloid
d. Jelly

41. The disintegration of tablet within its prescribed time is due to presence of
a. Talc
b. Diluent
c. Starch
d. Acacia

42. Agglomeration of particles in emulsion is called as
a. Polymerization
b. Coalescence
c. Dimerization
d. Dichromatism

43. HLB value of tragacanth is
a. 4.7
b. 13.2
c. 14.3
d. 8.9

44. Mixing is also called as
a. Cooling
b. Separating
c. Blending
d. Grinding

45. Lipophilic agent in HLB scale is
a. Towards zero
b. Towards 18
c. Both
d. None

46. In case of suppositories SFI stands for
a. Solidified fatty acid Indices
b. Solid fluid Indices
c. Solidified fatty incline
d. Solid fat index

47. Detergent usually have an HLB of
a. 0 – 3
b. 6-9
c. 9-12
d. 13-16

48. Example of monophasic liquid dosage
a. Elixir
b. Syrup
c. Drops
d. All of the above

49. Aromatic waters are prepared by
a. Maceration
b. Distillation
c. Condensation
d. Triple maceration

50. Isoelectric point pf Type A gelatin is
a. pH 7.0
b. pH 4.7
c. pH 9.0
d. pH 7.4

Type B gelatin, isoelectric pH point is 4.7