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Pharmacy License and Loksewa Exam Medicinal Chemistry Questions

Medicinal Chemistry Questions

Pharma Info Nepal by Pharma Info Nepal
December 27, 2020
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Pharmacy License and Loksewa Exam Medicinal Chemistry Questions
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Pharmacy License and Loksewa Exam Medicinal Chemistry Questions

Medicinal Chemistry is a important subject for Nepal Pharmacy Council License Exam and Pharmacy Loksewa, In the past, most of the questions were not asked, but now many questions are asked from Medicinal Chemistry. Here are some important medicinal chemistry questions for you to practice.

1. Which step in not involved in Phase I reaction?
a. Oxidation
b. Reduction
c. Hydrolysis
d. Conjugation

2. Nitroimadazole derivatives are
a. Metronidazole
b. Albendazole
c. Mebendazole
d. All of above 

3. Which of the following drugs is pyrimidine base antagonist?
a. Cytrabin
b. Tegafur
c. Capcitabin
d. All of above

4. Which of the following is not prodrug?
a. Progunil
b. Sulfasalazine
c. Pronstosil red
d. Trimethoprim 

5.  Which of the following starting materials for synthesis of salbutamol?
a. Phenyl acetonitrile
b. Methyl salicylate
c. 4- Hydroxy propiophenone 
d. Mesitylene derivatives

6. For antianginal activity, the nitrate derivate must be metabolized into:
a. Nitric acid 
b. Nitrous oxide
d. Both
d. None

7. Fursemide contains _______ ring
a. Furan 
b. Imidazole
c. Oxazole
d. Thiazole

8. Paracetamol undergoes metabolism by
a. N-hydroxylation
b. Deamination
c. O-dealkylation
d. Oxidative deamination

9. Penicllin on acid degradiation it gives
a. Penicillamine
b. Penilloic acid
c. Penicillo – aldehyde
d. All of above

10.Barbiturates are
a. Derived from malonic acid
b. Cyclic ureides
c. Urea derivatives
d. All of the above

11. Toxic metabolite of paracetamol which causes hepatotoxicity is
a. N-acetyl p-benzoquinone imine
b. N-acetyl p-benzoquinone amine
c. O-dealkyl acetaminophen
d. None

12. The introduction of -OCH2 group into the molecule between the aromatic ring and the ethyl amine side chain provides
a. Beta blocking agent 
b. Alpha blocking agent
c. Both
d. None

13. Modification on phenolic hydroxyl group __________  the activity of opoids.
a. Increase
b. Decrease 
c. No change
d. All

14. The greater the branching, barbiturates will be__________
a. Less Potent
b. More Potent 
c. No change
d. None of above

15. In limit test for arsenic which of following method used ?
a. Arsine test
b. Gutzeit test
c. Both
d. None

16. Which of the following drug was not isolated from a natural source?
a. Artemisinin
b. Morphine
c. Quinine
d. Isoniazid 

17. Which of the following is not endogenous compound?
a. Dopamine
b. Endorphins
c. Noradrenaline
d. Desipramine 

18. Methylation on morphine gives
a. Morphine
b. Codeine 
c.  Heroin
d. Fentanyl

19. _________ is known as diacetylmorphine
a. Morphine
b. Codeine 
c.  Heroin
d. Fentanyl

20. Which of the following is a natural chemical messenger for the adrenergic receptor?
a. Acetylcholine
b. Dopamine
c. Serotonin
d. Noradrenaline 

21. Which of the following Acetylcholine esterase inhibitor does not contain quaternary ammonium group?
a. Physostigmine
b. Neostigmine
c. Pyridostigmine
d. Edrophonium

22. Which substituent in celecoxib is responsible precluding binding with COX I enzyme?
a. Sulfamoyl
b. Phenyl
c. Methyl
d. Trifluromethyl

23. Identify metabolite of diazepam from the following.
a. Chlordiazepoxide
b. Oxazepam
c. Nitrazepam
d. Clonazepam

24. Name a NSAID associated with minimal gastric side effects
a. Diclofenac
b. Flurbiprofen
c. Aspirin
d. Nabumetone

25. Name of oxide derivative used as sedative hypnotic is
a. Diazepam
b. Chlordiazepoxide
c. Nitazepam
d. Ramelteon

26. Donepezil contains which heterocycle as scaffold?
a. Pyridine
b. Piperidine
c. Piperazine
d. Pyrazine

27. Which of the following NSAID is a prodrug?
a. Ibuprofen
b. Indometahcin
c. Diclofenac
d. Sulindac

28. Diazepam is metabolized to Nordazepam by ________and________.
a. CYP2C19 & CYP3A4
b. CYP2C18 & CYP3A3
c. CYP2C17 & CYP3A2
d. CYP2C20 & CYP3A5

29. If additional unsaturation is introduced in the Ring A in Gluocorticoids, it results in
a. Increase in Glucocorticoid activity
b. Changes the conformation of A ring
c. Enhance anti-inflammatory effect
d. Decreases Salt retaining activity

30. In case of Phenothiazine –Cl group at 2nd position and 3 C chain separating N10 and amino nitrogen is essential because ———-.
a. It is important for lipophilicity
b. It gives dopamine like arrangement
c. To maintain potency
d. It increases CNS penetration.


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