• About
  • Privacy Policy
  • Terms Of Use
  • Contact
Tuesday, March 2, 2021
Pharma Info Nepal
  • Home
  • Notice
  • Downloads
  • License
  • Loksewa
  • Vacancy
  • Questions
No Result
View All Result
  • Home
  • Notice
  • Downloads
  • License
  • Loksewa
  • Vacancy
  • Questions
No Result
View All Result
Pharma Info Nepal
No Result
View All Result
Home Updates

Don’t Use Some Drugs with Grapefruit

Don't Use Some Drugs with Grapefruit

Nabin Bista by Nabin Bista
February 23, 2021
in Updates
0
Don't Use Some Drugs with Grapefruit
153
VIEWS
Share on FacebookShare on Twitter

Don’t Use Some Drugs with Grapefruit

Grapefruit juice can affect how well some medicines work, and it may cause dangerous side effects.

Grapefruit juice and the actual grapefruit can be part of a healthy diet. Grapefruit has vitamin C and potassium nutrients your body needs to work properly.

But it isn’t good for you when it affects the way your medicines work, especially if you have high blood pressure or arrhythmia (irregular or abnormal heart beat).

Here are examples of some types of drugs that grapefruit juice can cause problems with (interact):

  • Some statin drugs to lower cholesterol, such as simvastatin and atorvastatin.
  • Some drugs that treat high blood pressure, nifedipine.
  • Some organ-transplant rejection drugs, such as cyclosporine.
  • Some anti-anxiety drugs, such as buspirone.
  • Some corticosteroids that treat Crohn’s disease or ulcerative colitis, such as budesonide.
  • Some drugs that treat abnormal heart rhythms, such as amiodarone.
  • Some antihistamines, such as fexofenadine.

Grapefruit juice does not affect all the drugs in the categories above. The severity of the interaction can be different depending on the person, the drug, and the amount of grapefruit juice you drink. Talk to your doctor, pharmacist or other health care provider and read any information provided with your prescription or OTC drug to find out:

  • If your specific drug may be affected.
  • How much, if any, grapefruit juice you can have.
  • What other fruits or juices may also affect your drug in a similar way to grapefruit juice.

How Grapefruit Juice Can Interfere With Medications

With most drugs that interact with grapefruit juice, “the juice lets more of the drug enter the blood, “When there is too much drug in the blood, you may have more side effects.”

For example, if you drink a lot of grapefruit juice while taking certain statin drugs to lower cholesterol, too much of the drug may stay in your body, increasing your risk for liver and muscle damage that can lead to kidney failure.

Many drugs are broken down (metabolized) with the help of a vital enzyme called CYP3A4 in the small intestine. Grapefruit juice can block the action of CYP3A4, so instead of being metabolized, more of the drug enters the blood and stays in the body longer. The result: too much drug in your body.

The amount of the CYP3A4 enzyme in the intestine varies from person to person. Some people have a lot of enzymes and others just a little. So grapefruit juice may affect people differently even when they take the same drug.

Although scientists have known for several decades that grapefruit juice can cause too much of certain drugs in the body, more recent studies have found that the juice has the opposite effect on a few other drugs.

“Grapefruit juice can cause less fexofenadine to enter the blood,” decreasing how well the drug works. Fexofenadine (brand name Allegra) is available as both prescription and OTC to relieve symptoms of seasonal allergies. Fexofenadine may also not work as well if taken with orange or apple juice, so the drug label states “do not take with fruit juices.”

Why this opposite effect? Instead of changing metabolism, grapefruit juice can affect proteins in the body known as drug transporters, which help move a drug into our cells for absorption. As a result, less of the drug enters the blood and the drug may not work as well.

How Grapefruit Juice Affects Some Drugs

When drugs are swallowed, they may be broken down (metabolized) by enzymes and/or absorbed using transporters in cells found in the small intestine. Grapefruit juice can cause problems with these enzymes and transporters, causing too much or too little drug in the body.

Don't Use Some Drugs with Grapefruit

Some drugs, like statins used to lower cholesterol, are broken down by enzymes. As shown above, grapefruit juice can block the action of these enzymes, increasing the amount of drug in the body and may cause more side effects.

Don't Use Some Drugs with Grapefruit

Other drugs, like Allegra (fexofenadine) used to treat allergies, are moved by transporters into the body’s cells. As shown above, grapefruit juice can block the action of transporters, decreasing the amount of drug in the body and may cause the drug to not work as well.

Find Out if You Should Avoid Grapefruit or Other Juices

  • Ask your doctor, pharmacist or other health care provider if you can drink grapefruit juice while taking your medication.
  • Read the medication guide or patient information sheet that comes with your prescription drug to find out if grapefruit juice affects your drug.
  • Read the Drug Facts label on your OTC drug, which will say whether you shouldn’t have grapefruit or other fruit juices with it.
  • If you must avoid grapefruit juice with your medicine, check the labels of fruit juices or drinks flavored with fruit juice to see whether they are made with grapefruit juice.
  • Do not eat those fruits if your medicine interacts with grapefruit juice.

Reference: FDA Guidelines 


  • Medication Alternatives for High Blood Pressure
  • Guidelines for Drug Donation to Nepal
  • How to Learn Drug’s Name and Classification

 

Tags: Medicine InformationPharmacy Updates
Previous Post

How to Learn Drug’s Name and Classification

Next Post

Vacancy Announcement Deurali Janta Pharmaceuticals

Nabin Bista

Nabin Bista

Hello, Thank You for visiting my blog I am Nabin Bista, Dedicated and self motivated young Pharmacist from Nepal. Blogging is my passion. I am working at Patan Hospital and studying B Pharmacy at Institute of Medicine - IOM. If you want me to write about any posts that you found confusing/difficult, please mention in the comments below.

Related Posts

Department of Drug Adminsitration (DDA)

Department of Drug Administration (DDA)

March 2, 2021
Classes of antibiotics and their Spectrum of Activity

Classes of Antibiotics and their Spectrum of Activity

March 2, 2021
History of the development of pharmacy profession in Nepal

History of Pharmaceutical Development in Nepal

February 27, 2021
Classification of Drugs in Nepal 

Classification of Drugs in Nepal 

February 27, 2021
Load More
Next Post
Vacancy Announcement Deurali Janta Pharmaceuticals

Vacancy Announcement Deurali Janta Pharmaceuticals

Discussion about this post

Recommended

Nepal Pharmacy Council License Exam Past Question Collection

Nepal Pharmacy Council License Exam Past Question Collection

2 months ago
Loksewa Aayog Pharmacy Supervisor Vacancy Announcement

Loksewa Aayog Pharmacy Supervisor Vacancy Announcement

3 weeks ago

Don't Miss

Department of Drug Adminsitration (DDA)

Department of Drug Administration (DDA)

March 2, 2021
Classes of antibiotics and their Spectrum of Activity

Classes of Antibiotics and their Spectrum of Activity

March 2, 2021
BNS (Bachelor in Nursing Science) Entrance Exam Syllabus

BNS (Bachelor in Nursing Science) Entrance Exam Syllabus

March 2, 2021
History of the development of pharmacy profession in Nepal

History of Pharmaceutical Development in Nepal

February 27, 2021

About Pharma Info Nepal

Pharma Info Nepal (Nabin’s Blog) is popular Pharmacy information sharing online platform initiated by Pharmacist Nabin Bist. The main purpose of this platform is to share pharma updates, information & opportunities for pharmacy professionals. Because of continuous effort and dedication, thousands of pharmacy professionals have trusted this website as a primary platform to find the latest pharma updates in Nepal. So the admin is doing his best for accurate, trusted, up-to-date pharma information & opportunities to all pharmacy professionals

Follow us

INFORMATION READER

The content, resources, documents, guidelines, and information on this blog have been collected from various sources. Dedicated to the pharmacy profession without the purpose of spreading any illusions and rumors. If you have any complaints or suggestions, please feel free to contact at Pharmainfonepal1@gmail.com

Also, the content here will not be used for any purpose. If found stolen, action will be taken according to the prevailing law

Categories

  • Downloads
  • License
  • Loksewa
  • Notice
  • Nursing
  • Questions
  • Syllabus
  • Updates
  • Vacancy

DOWNLOADS

Pharmacy Book 

Pharmacy Act and Guidelines

About Pharma Info Nepal

About Admin

  • About
  • Privacy Policy
  • Terms Of Use
  • Contact

© 2020 Pharma Info Nepal.

No Result
View All Result
  • Home
  • Notice
  • Downloads
  • License
  • Loksewa
  • Vacancy
  • Questions

© 2020 Pharma Info Nepal.

error: