M Pharmacy Entrance Exam Model Question

M Pharmacy Entrance Exam Model Question based on the syllabus of Medical Education Comission. Now in Nepal M Pharmacy Entrance Exam is under the Medical Education Comission.

1. Acetylcholine and physostigmine are examples of__________ type drug interaction.
(a) Synergism
(b) Addition
(c) Potentiation
(d) Antagonism

Ans. C

2. Drug of choice in motion sickness is
(a) Atropine
(b) Scopolamine
(c) Carbamazepine
(d) Metoclopromide

Ans. B

3. In a patient of chronic asthma on treatment with theophyline, which of the following should not be used to treat his upper respiratory tract infection?
(a) Ampicillin
(b) Cephalexin
(c) Erythromycin
(d) All

Ans. C

4. Advantage of salmeterol over salbutamol is its:
(a) Shorter duration of action
(b) More potency
(c) Longer duration of action
(d) Lesser cardiac effects

Ans. C

5. Which of the following intravenous anesthetic agents is contraindicated in epileptic patients posted for general anesthesia?
(a) Ketamine
(b) Thiopentone
(c) Propofol
(d) Midazolam

Ans. A

6. All of the following adverse effects are associated with the use of proton pump inhibitors except:
(a) Community acquired pneumonia
(b) Clostridium difficile infection
(c) Osteoporosis leading to hip fracture
(d) Hypothyroidism

Ans. D

7. A person consumes large quantities of alcohol daily since 20 years. He is physically dependent on alcohol. Drug that should not be given to this person is:
(a) Disulfiram
(b) Acamprosate
(c) Naltrexone
(d) Chlordiazepoxide

Ans. A

8. The transition from excited state to ground state is called.
(a) Excitation
(b) Absorption
(c) Relaxation
(d) Scatterin
Ans. c

9. The solvent not used in IR spectroscopy is
(a) Chloroform
(b) Carbon tetra chloride
(c) Carbon disulfite
(d) Water
Ans. d

10. Which one of the following propellant is used in the aerosol for oral use?
(a) Propane
(b) Oxygen
(c) Methane
(d) Trichloro monofluoro methane
Ans. d

11. Sodium starch glycollate is used as
(a) Glidant
(b) Lubricant
(c) Disintigrant
(d) Binder
Ans. c

12. The most commonly used humectants in tooth paste includes
(a) Glycerol
(b) Sorbitol
(c) Both a & b
(d) None of these
Ans. c

13. Which treatment is used for solubility of gelatin?
(a) Heat
(b) Formalin
(c) Water
(d) Alcohol
Ans. b

14. Empty capsule has moisture content in the range of
(a) 60%
(b) 12%-15 %
(c) 50%- 70%
(d) 30%
Ans. b

15. Which of the following is not factor or renal excrection
(a) Blood flow to kidneys
(b) Urine pH
(c) Blood pH
(d) Disease condition
Ans. c

16. How do you calculate the rate of excretion by kidneys
(a) Rate of filtration – rate of secretion – rate of absorption
(b) Rate of filtration + rate of secretion – rate of absorption
(c) Rate of filtration + rate of secretion + rate of absorption
(d) Rate of filtration – rate of secretion + rate of absorption
Ans. b

17. Sodium methoxide is standardized by
(a) Oxallic acid
(b) Perchloric acid
(c) Acetic acid
(d) Benzoic acid
Ans. d

18. To study the stress and rate of shear, the phenomenon of converting gel to sol is known as
(a) Plastic flow
(b) Pseudo plastic flow
(c) Thixotropy
(d) Dilatant flow
Ans. b

19. Pseudoplastic flow is typically exhibited by
(a)Emulsion
(b) Polymer solution
(c) Suspension
(d) Ointment
Ans. b

20. Which of the following surfactant also possess antibacterial activity?
(a) Glyceryl monostearate
(b) Quaternary ammonium compounds
(c) Sodium oleate
(d) Sodium lauryl sulphate
Ans. b

21. Following is not a derived property of powder:
(a) Surface area
(b) Particle size
(c) Bulk density
(d) None
Ans. c

22. The release of maintenance dose in sustained release
dosage form should follow
(a) Zero-order kinetics
(b) First-order kinetics
(c) Second-order kinetics
(d) Pseudo-order kinetics
Ans. a

23. How much solvent is required to dissolve a sparingly soluble salt?
(a) 10 to 30 parts
(b) 1 to 10 parts
(c) 100 to 150 parts
(d) 100 to 1000 parts
Ans. d

24. Duhring’s rule is related to
(a) Crystallization
(b) Distillation
(c) Filtration
(d) Size reduction
Ans. b

25. For effective screening of all bacteria for sterilization of liquids the membrane pore size is
(a) 0.2µm
(b) 0.45µm
(c) 0.8µm
(d) 1.2µm
Ans. a

26. Hammer mill works by following principle:
(a) Impact
(b) Attrition
(c) Compression
(d) None
Ans. a

27. Select a mill for a low melting drug.
(a) Hammer mill
(b) Roller mill
(c) Ball mill
(d) Fluid energy mill.
Ans. d

28. Deficiency of which of the following causes respiratory distress syndrome?
(a) Phosphetidylserine
(b) Sphingomyelin
(c) Plasmogens
(d) Dipalmitoyllecithin
Ans. d

29. Which hormone is released at all postganglionic sympathetic fiber?
(a) Adrenaline
(b) Dopamine
(c) Noradrenaline
(d) Isoprenaline
Ans. a

30. The steroid having role in promoting maturation of the lung in foetus is
(a) Androgen
(b) Estrogen
(c) Progestine
(d) Glucocorticoids
Ans. d

31. The solvent not used in IR spectroscopy is
(a)Chloroform
(b) Carbon tetra chloride
(c) Carbon disulfite
(d) Water
Ans. d

32. The following is an example for atomic spectra:
(a) UV spectra
(b) Colorimetry
(c) Flourimetry
(d) Flame photometry
Ans. d

33. Flame photometry cannot be used for:
(a) Barium
(b) Calcium
(c) Selenium
(d) Sodium
Ans. c

34. Which antihypertensive drug has to be avoided in a diabetic patient ho is taking insulin?
(a) Guanethidine
(b) α-methyl dopa
(c) Propranolol
(d) Hydralazine
Ans. c

35. Calcium channel blocker with predominant peripheral action is
(a) Nicardepine
(b) Verapamil
(c) Nifedepine
(d) Diltiazem
Ans. c

36. Aspirin should not be used in ____________
(a) Gout
(b) Myocardial infarction
(c) Both a and b
(d) None of the above
Ans. a

37. Example of stimulant purgative is
(a) Ispaghula husk
(b) Cisapride
(c) Senna
(d) Lactulose
Ans. c

38. Magnesium aluminium silicate is used as
(a) Oral rehydration salt
(b) Absorbent
(c) Antimotility agent
(d) Anti emetic agent
Ans. b

39. Ursodeoxycholic acid is used in the treatment of
(a) Jaundice
(b) Urinary tract infection
(c) Malaria
(d) Gastrointestinal tract infection
Ans. a

40. Biosynthesis of isothiocyanate aglycone follows
(a) Acetate pathway
(b) Mevalonate pathway
(c) Shikkimic pathway
(d) None of the above
Ans. a

41. In HDL ___________ of triacylglycerol is present.
(a) 88%
(b) 55%
(c) 12%
(d) 98%
Ans. a

42. Toxoids are used for ______________
(a) Tuberculosis
(b) Typhoid
(c) Enteric fever
(d) Diphtheria
Ans. d

43. Paracetamol is assayed by
(a) Ceric ammonium sulphate
(b) I2
(c) HPLC
(d) KIO3
Ans. a

44. In gas chromatography sample must be in
(a) Solid state
(b) Gas state
(c) Liquid state
(d) Crystal
Ans. b

45. Drug having high affinity but low intrinsic activity is called
(a) Partial agonist
(b) Antagonist
(c) Non-competitive antagonism
(d) Competitive antagonism
Ans. a

46. Following drugs have volume of distribution more than 200:
(a) Warfarin
(b) Digoxin
(c) Alcohol
(d) None
Ans. b

47. Acetylcholine and physostigmine are examples of __________ type drug interaction.
(a) Synergism
(b) Addition
(c) Potentiation
(d) Antagonism
Ans. c

48. Bioassays are carried out to:
(a) Measure the pharmacological activity of a drug
(b) Avoid clinical trials for new drugs
(c) Detect the impurity in a given drug
(d) Screen from pharmacogenetic influences of new drugs
Ans. a

49. Most common Phase-II reaction is
(a) Sulfate conjugation:
(b) Glucuronide conjugation
(c) α amino acid conjugation
(d) Methylation
Ans. b

50. Which of the following receptor shows the slowest response?
(a) GPCR
(b) Ion channel
(c) Enzyme linked
(d) Steroid receptor
Ans. d