Pharmaceutical Analysis Questions for Pharmacy License and Loksewa Exam

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Pharmaceutical Analysis Questions for Pharmacy License and Loksewa Exam

1.The color of phenolphthalein in alkali medium is
a.Pink
b.Colorless
c.Blue
d.Orange

2.According to Lewis Theory, acids are
a.Proton acceptor
b.Proton donor
c.Electron acceptor
d.Electron donor

3.What is a red shift
a.The shifting of an absorption to shorter wavelength
b.The shifting of an absorption towards the blue end of the spectrum
c.The shifting of an absorption to higher energy
d.The shifting of absorption to lower energy

4.In UV-spectrophotometer sample cell is made up of
a.Glass
b.Quartz
c.Both
d.None

5.In reverse phase chromatography , the stationary phase is
a.Non-polar
b.Polar
c.Either polar or non-polar
d.None of these

6.The solution of known concentration is known as
a.Buffer solution
b.Standard solution
c.Neutral solution
d.Saturated solution

7.Which solvent can be used in non-aqueous titration
a.Acetic acid
b.Glacial acetic acid
c.Semi normal acetic acid
d.All of the above

8.In Kjeldahl method, sample containing nitrogen is digested with
a.Conc. NaOH
b.Fuming HNO3
c.Conc. H2SO4
d.Strong NH3 solution

9.In Gas-Liquid Chromatography, some of the samples need to be derivatized in order to increase their
a.Solubility
b.Thermal conductivity
c.Polarizability
d.Volatility

10.The characteristic properties of an acid is due to the presence of
a.Hydride ions
b.Hydroxyl ions
c.Hydronium ions
d.Oxide ions

11.The fluid exiting in a chromatographic column is known as
a.Eluent
b.Eluate
c.Analyte
d.All of above

12.In normal phase chromatography, stationary phase is
a.Non polar
b.Polar
c.Neutral
d.None of the above

13.The sample cell commonly used in a fluorimeter is made of
a.Quartz
b.Fused silica
c.Polystyrene
d.Glass

14.Ascorbic acid tablets can be assayed by
a.Titration with iodine solution
b.Oxidation involving 2,6-dichloro phenol indophenols
c.Titration with ceric ammonium sulphate
d.Titration with sodium hydroxide solution

15.An acceptor of pair of electron is termed as
a.Nucleophile
b.Electrophile
c.Carbocation
d.Anion

16.Which of the following compound does not absorb light in the UV/ visible spectrum?
a.Aspirin
b.Paracetamol
c.Chloral hydrate
d.Phenobarbitone

17.Beer lambert’s law gives the relation between which of the following
a.Reflected radiation and concentration
b.Energy absorption and concentration
c.Scattered radiation and concentration
d.Energy absorption and reflected radiation

18.Choose the acid salt from the following
a.NaNO3
b.Na2SO4
c.NaHSO4
d.Na2CO3

19.1 M of HCl is equivalent to
a.1N HCl
b.2N HCl
c.0.5 N HCl
d.None of the above

20.The theory of color change of indicator during acid-base titration is given by
a.Arrhenius theory
b.Dalton’s theory
c.Bronsted- Lowry theory
d.Ostwald theory

21.The wavelength of an absorption is 495 nm. In which part of the electromagnetic spectrum does this lie?
a.Radio wave
b.UV-visible
c.Infrared
d.Microwave

22.Which of the following is the principle chromophore of an azo dye?
a.N = N
b.C = N
c.N = N
d.C = N

23.For the analysis of Vitamin B12, which of the micro-organism is used
a.Lactobacillus liechmanniis
b.Staphylococcus aureus
c.Micrococcus luteus
d.Pseudomonas aeruginosa

24.The main principle of separation of paper chromatography is
a.Adsorption
b.Partition coefficient
c.Ion exchange
d.Affinity

25.Which of the following is a general property of bases
a.Taste sour
b.Turns litmus red
c.Conduct electrical current in solution
d.Concentration of h3o+ is greater than concentration of OH

26.An Arrhenius acid is defined as a chemical species that
a.Is a proton donor
b.Is a proton acceptor
c.Produce hydroxyl ions ion solution
d.Produce hydrogen ion in the solution

27.Color of Methyl orange indicator in alkali medium is
a.Red
b.Pink
c.Orange
d.Yellow

28.pH range of Phenolphthalein is
a.5-6.5
b.6.5-7
c.7.5-8
d.8-10

29.pH range of methyl orange is
a.1-1.6
b.2-3
c.3.1-4.4
d.4.4-6.3

30.H2SO4 is a
a.Monoprotic acid
b.Polyprotic acid
c.Monoprotic base
d.Polyprotic base

31.Which of the following is a redox reaction
a.NaCl + KNO3? NaNO3 + KCl
b.CaC2O4 + 2HCl ? CaCl2 + H2C2O4
c.Mg(OH)2 + 2NH4Cl ?MgCl2 + 2NH4OH
d.Zn + 2AgCN ? 2Ag + Zn(CN)2

32.An oxidizing agent will always
a.Be reduced
b.Loss electron
c.Increase in oxidation number
d.Increase in mass

33.Iodometric titration is performed for the following solutions except
a.Strong acid and strong base
b.Strong acid and weak base
c.Weak acid and strong base
d.Weak acid and weak base

34.The suitable indicator for the titration of strong acid and weak base is
a.Methyl red
b.Methyl orange
c.Bromocresol green
d.All of the above

35.Indicator of complexometric titration
a.Murexide
b.Eriochrome black T
c.Calmagite
d.All of the above

36.Non aqueous titration is carried out for
a.Water insoluble drugs
b.Weakly acidic drug
c.Weakly basic drug
d.All

37.Which of the following is aprotic solvent
a.Ethanol
b.Water
c.Chloroform
d.Ethylene diamine

38.Protogenic solvent is
a.Sulphuric acid
b.Hydrochloric acid
c.Nitric acid
d.All if the above

39.Perchloric acid can be standardized by using
a.Benzoic acid
b.Oxalic acid
c.Potassium hydrogen phthalate
d.Tartaric acid

40.Which of the following is incorrect statement for gravimetric analysis
a.Precipitate must be free from soluble impurities
b.Precipitate must be insoluble in solution
c.Precipitates must not be readily separated from the solution by filtration
d.Precipitate must be convertible into a pure compound by ignition or by simple evaporation

41.Which of the following statement is correct for Karl Fischer Titration
a.Used for quantitative determination of water in pharmaceuticals
b.Karl Fischer reagent contain iodine, Sulphur dioxide, anhydrous methanol and anhydrous pyridine
c.Fundamental principle of Karl Fischer method is based on the Bunsen reaction.
d.All of the above

42.Locating agent of amino acid in chromatography is
a.Diazo reagent
b.Ninhydrin reagent
c.Amphoteric oxides
d.Neutral oxides

43.Adsorption in chromatography refers to
a.Bounding of a substance to the surface of another substance
b.Diffusion of one substance to the bulk of other substance completely
c.Boiling of liquid at the surface
d.An inability to bond something at the surface

44.Pattern on paper in chromatography is called
a.Chroming
b.Chroma
c.Chromatograph
d.Chromatogram

45.Mobile phase can be
a.Gas or liquid
b.Solid or liquid
c.Only solid
d.Only gas

46. Thin layer chromatography is
a.Partition chromatography
b.Electrical mobility of ionic species
c.Adsorption chromatography
d.None of the above

47.In gas chromatography, the basis of separation of the components of the volatile material is the difference in
a.Partition coefficient
b.Conductivity
c.Molecular weight
d.Molarity

48.Ion exchange chromatography is based on
a.Electrostatic attraction
b.Electrical mobility of ionic species
c.Adsorption chromatography
d.Partition chromatography

49.A combination of paper chromatography and electrophoresis involves
a.Partition coefficient
b.Electrical mobility of the ionic species
c.Both a and b
d.Bone of these

50.Tailing of the peak is minimized in gas chromatography by
a.Hexa methyl disilazane
b.Hexa ethyl disilazane
c.Ethyl disilazane
d.Penta methyl disilazane

51.Chromatography with solid stationary phase is called
a.Circle chromatography
b.Square chromatography
c.Solid chromatography
d.Adsorption chromatography

52.In reverse phase chromatography, the stationary phase is made
a.Non-polar
b.Polar
c.Either polar or non-polar
d.None of these

53.A/ An ………… is the detector of choice for GC separation of halogenated compound
a.Electron capture detector
b.Flame ionization detector
c.Thermal conductivity detector
d.Universal detector

54.Which would be a suitable carrier gas to use in gas chromatography
a.Oxygen
b.Nitrogen
c.Fluorine
d.Ammonia

55.Most commonly used detector in HPLC is
a.Refractive index detector
b.Fluorescence detector
c.UV detector
d.Electrochemical detector

56.Which of the following is not used as an stationary phase in adsorption thin layer chromatography
a.Cellulose
b.Silica gel
c.Aluminum oxide
d.Polyamide

57.In isocratic technique
a.Solvent of same polarity is used throughout the process of separation
b.Solvent of gradually increasing polarity are used throughout the process of separation
c.Solvent of gradually decreasing polarity are used throughout the process of separation
d.None of the above

58.Which of the following compound does not absorb light in the YV/Visible spectrum
a.Aspirin
b.Paracetamol
c.Chloral hydrate
d.Phenobarbitone

59.What is red shift
a.The shifting of an absorption towards shorter wavelength
b.The shifting of an absorption towards the blue end of the spectrum
c.The shifting of an absorption towards the higher energy
d.The shifting of an absorption towards to lower energy

60.What is a chromophore
a.A group of atoms in a colored compound
b.A colored compound
c.A group of atoms in a compound responsible for the absorption of electromagnetic radiation
d.A group of atoms in a compound responsible for electromagnetic radiation

61.A shift to lower wavenumber for an absorption in a spectrum corresponds to
a.A shift to lower frequency
b.A shift to lower wavelength
c.A shift to higher energy
d.A loss of intensity

62.Instrument to measure the absorbance of color compound
a.Colorimeter
b.Coulometer
c.Colormeter
d.calorimeter

63.In which region of electromagnetic spectrum does an absorption at 600nm come
a.Visible
b.Vacuum-UV
c.Infrared
d.Near-uv

64.Principle chromophore of azo-dye
a.N=N
b.C=N
c.N=N
d.C=N

65.If % transmittance is 0, then absorbance is
a.0
b.0-1
c.1
d.Infinity

66.Lambert’s law establish relationship between
a.Absorbance and wavelength
b.Absorbance and concentration
c.Concentration and transmittance
d.Wavelength and concentration

67.What is the correct sequence for the process occurring in a mass spectroscopy
a.Ionization, vaporization, deflection, acceleration
b.Vaporization, ionization, acceleration, deflection
c.Vaporization, acceleration, ionization, deflection
d.Ionization, vaporization, acceleration, deflection

68.Following group has the IR range of 2100-2200 cm-1
a.C=C stretching
b.C=C stretching
c.C=O stretching
d.C-C stretching

69.Reference standard in NMR in aqueous solution
a.Tetra methyl silane
b.Tri methyl silane
c.Triethylsilyl propanesulphonic acid
d.Trimethyl silylpropanepentanoic acid

70.IR radiation source
a.Deuterium discharge lamp
b.Mercury arc lamp
c.Incandescent lamp
d.None

71.Following are UV-Visible and IR detectors respectively
a.Bolometer and PMT
b.Thermal conductivity and PMT
c.PMT and bolometer
d.PMT and thermal conductivity

72.Neujol is a
a.Vegetable oil
b.Fixed oil
c.Mineral oil
d.Edible oil

73.Which of the following is not an absorption spectroscopy
a.UV spectroscopy
b.Calorimetry
c.NMR
d.Flame photometry

74.The thickness of the sample medium in UV-Visible spectroscopy is related to
a.Beer’s law
b.Lambert’s law
c.Beer-Lambert’s law
d.None

75.Maximum energy required for the fragmentation to occurs in mass spectroscopy is
a.70KeV
b.70 meV
c.70 ev
d.70 Mev

76.Which of the following does not involves interaction of molecules with electromagnetic energy
a.IR spectroscopy
b.Mass spectroscopy
c.UV spectroscopy
d.NMR spectroscopy

77.The difference between measured value and true value is known as
a.Precision
b.Accuracy
c.Precision and accuracy
d.Reproducibility

78.Test micro-organism for the essay of Vit- B12 is
a.Staphylococcus aureus
b.Saccharomyces cerevisiae
c.Micrococcus luteus
d.Lactobacillus liechmanni

79.The region mostly used for IR spectroscopy is
a.Near IR
b.Mid-IR
c.Far IR
d.Very far IR

80.Mercury lamp is used as radiation source in which technique?
a.Colorimetry
b.Flourimetry
c.UV visible spectroscopy
d.Infrared

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